3B11-N, a monoclonal antibody against MERS-CoV, reduces lung pathology in rhesus monkeys following intratracheal inoculation of MERS-CoV Jordan-n3/2012
Identifieur interne : 001422 ( Main/Exploration ); précédent : 001421; suivant : 0014233B11-N, a monoclonal antibody against MERS-CoV, reduces lung pathology in rhesus monkeys following intratracheal inoculation of MERS-CoV Jordan-n3/2012
Auteurs : Reed F. Johnson [États-Unis] ; Ulas Bagci [États-Unis] ; Lauren Keith [États-Unis] ; Xianchun Tang [États-Unis] ; Daniel J. Mollura [États-Unis] ; Larry Zeitlin [États-Unis] ; Jing Qin [États-Unis] ; Louis Huzella [États-Unis] ; Christopher J. Bartos [États-Unis] ; Natasha Bohorova [États-Unis] ; Ognian Bohorov [États-Unis] ; Charles Goodman [États-Unis] ; Do H. Kim [États-Unis] ; Michael H. Paulty [États-Unis] ; Jesus Velasco [États-Unis] ; Kevin J. Whaley [États-Unis] ; Joshua C. Johnson [États-Unis] ; James Pettitt [États-Unis] ; Britini L. Ork [États-Unis] ; Jeffrey Solomon [États-Unis] ; Nicholas Oberlander [États-Unis] ; Quan Zhu [États-Unis] ; Jiusong Sun [États-Unis] ; Michael R. Holbrook [États-Unis] ; Gene G. Olinger [États-Unis] ; Ralph S. Baric [États-Unis] ; Lisa E. Hensley [États-Unis] ; Peter B. Jahrling [États-Unis] ; Wayne A. Marasco [États-Unis]Source :
- Virology [ 0042-6822 ] ; 2016.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux (administration et posologie), Anticorps monoclonaux (administration et posologie), Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie), Humains, Infections à coronavirus (anatomopathologie), Infections à coronavirus (traitement médicamenteux), Infections à coronavirus (virologie), Macaca mulatta, Modèles animaux de maladie humaine, Mâle, Poumon (anatomopathologie), Poumon (virologie).
- MESH :
- administration et posologie : Anticorps antiviraux, Anticorps monoclonaux.
- anatomopathologie : Infections à coronavirus, Poumon.
- physiologie : Coronavirus du syndrome respiratoire du Moyen-Orient.
- traitement médicamenteux : Infections à coronavirus.
- virologie : Infections à coronavirus, Poumon.
- Animaux, Humains, Macaca mulatta, Modèles animaux de maladie humaine, Mâle.
English descriptors
- KwdEn :
- Animals, Antibodies, Monoclonal (administration & dosage), Antibodies, Viral (administration & dosage), Coronavirus Infections (drug therapy), Coronavirus Infections (pathology), Coronavirus Infections (virology), Disease Models, Animal, Humans, Lung (pathology), Lung (virology), Macaca mulatta, Male, Middle East Respiratory Syndrome Coronavirus (physiology).
- MESH :
- chemical , administration & dosage : Antibodies, Monoclonal, Antibodies, Viral.
- drug therapy : Coronavirus Infections.
- pathology : Coronavirus Infections, Lung.
- physiology : Middle East Respiratory Syndrome Coronavirus.
- virology : Coronavirus Infections, Lung.
- Animals, Disease Models, Animal, Humans, Macaca mulatta, Male.
Abstract
Middle East Respiratory Syndrome Coronavirus (MERS-CoV) was identified in 2012 as the causative agent of a severe, lethal respiratory disease occurring across several countries in the Middle East. To date there have been over 1600 laboratory confirmed cases of MERS-CoV in 26 countries with a case fatality rate of 36%. Given the endemic region, it is possible that MERS-CoV could spread during the annual Hajj pilgrimage, necessitating countermeasure development. In this report, we describe the clinical and radiographic changes of rhesus monkeys following infection with 5×106 PFU MERS-CoV Jordan-n3/2012. Two groups of NHPs were treated with either a human anti-MERS monoclonal antibody 3B11-N or E410-N, an anti-HIV antibody. MERS-CoV Jordan-n3/2012 infection resulted in quantifiable changes by computed tomography, but limited other clinical signs of disease. 3B11-N treated subjects developed significantly reduced lung pathology when compared to infected, untreated subjects, indicating that this antibody may be a suitable MERS-CoV treatment.
Url:
DOI: 10.1016/j.virol.2016.01.004
PubMed: 26828465
PubMed Central: 4769911
Affiliations:
- États-Unis
- Caroline du Nord, Floride, Maryland, Massachusetts
- Chapel Hill (Caroline du Nord)
- Université de Caroline du Nord à Chapel Hill
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Le document en format XML
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Holbrook</name><affiliation wicri:level="2"><nlm:aff id="aff0015">Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Olinger, Gene G" sort="Olinger, Gene G" uniqKey="Olinger G" first="Gene G." last="Olinger">Gene G. Olinger</name><affiliation wicri:level="2"><nlm:aff id="aff0015">Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Baric, Ralph S" sort="Baric, Ralph S" uniqKey="Baric R" first="Ralph S." last="Baric">Ralph S. Baric</name><affiliation wicri:level="4"><nlm:aff id="aff0035">Department of Microbiology and Immunology, Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599</wicri:regionArea><placeName><region type="state">Caroline du Nord</region><settlement type="city">Chapel Hill (Caroline du Nord)</settlement></placeName><orgName type="university">Université de Caroline du Nord à Chapel Hill</orgName></affiliation></author><author><name sortKey="Hensley, Lisa E" sort="Hensley, Lisa E" uniqKey="Hensley L" first="Lisa E." last="Hensley">Lisa E. Hensley</name><affiliation wicri:level="2"><nlm:aff id="aff0015">Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Jahrling, Peter B" sort="Jahrling, Peter B" uniqKey="Jahrling P" first="Peter B." last="Jahrling">Peter B. Jahrling</name><affiliation wicri:level="2"><nlm:aff id="aff0005">Emerging Viral Pathogens Section National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Emerging Viral Pathogens Section National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff0015">Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Marasco, Wayne A" sort="Marasco, Wayne A" uniqKey="Marasco W" first="Wayne A." last="Marasco">Wayne A. Marasco</name><affiliation wicri:level="2"><nlm:aff id="aff0020">Department of Cancer Immunology & AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cancer Immunology & AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26828465</idno><idno type="pmc">4769911</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769911</idno><idno type="RBID">PMC:4769911</idno><idno type="doi">10.1016/j.virol.2016.01.004</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">001180</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001180</idno><idno type="wicri:Area/Pmc/Curation">001180</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001180</idno><idno type="wicri:Area/Pmc/Checkpoint">000C82</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000C82</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:26828465</idno><idno type="wicri:Area/PubMed/Corpus">001279</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001279</idno><idno type="wicri:Area/PubMed/Curation">001279</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001279</idno><idno type="wicri:Area/PubMed/Checkpoint">001259</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001259</idno><idno type="wicri:Area/Ncbi/Merge">001461</idno><idno type="wicri:Area/Ncbi/Curation">001461</idno><idno type="wicri:Area/Ncbi/Checkpoint">001461</idno><idno type="wicri:doubleKey">0042-6822:2016:Johnson R:b:n:a</idno><idno type="wicri:Area/Main/Merge">001427</idno><idno type="wicri:Area/Main/Curation">001422</idno><idno type="wicri:Area/Main/Exploration">001422</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">3B11-N, a monoclonal antibody against MERS-CoV, reduces lung pathology in rhesus monkeys following intratracheal inoculation of MERS-CoV Jordan-n3/2012</title><author><name sortKey="Johnson, Reed F" sort="Johnson, Reed F" uniqKey="Johnson R" first="Reed F." last="Johnson">Reed F. Johnson</name><affiliation wicri:level="2"><nlm:aff id="aff0005">Emerging Viral Pathogens Section National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Emerging Viral Pathogens Section National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Bagci, Ulas" sort="Bagci, Ulas" uniqKey="Bagci U" first="Ulas" last="Bagci">Ulas Bagci</name><affiliation wicri:level="1"><nlm:aff id="aff0010">Center for Infectious Disease Imaging, National Institutes of Health Clinical Center, Bethesda MD 20892, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Infectious Disease Imaging, National Institutes of Health Clinical Center, Bethesda MD 20892</wicri:regionArea><wicri:noRegion>Bethesda MD 20892</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:aff id="aff0040">Center for Research in Computer Vision (CRCV), Department of Electrics Electronics and Computer Science, University of Central Florida, Orlando, FL 32816, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Center for Research in Computer Vision (CRCV), Department of Electrics Electronics and Computer Science, University of Central Florida, Orlando, FL 32816</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Keith, Lauren" sort="Keith, Lauren" uniqKey="Keith L" first="Lauren" last="Keith">Lauren Keith</name><affiliation wicri:level="2"><nlm:aff id="aff0015">Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Tang, Xianchun" sort="Tang, Xianchun" uniqKey="Tang X" first="Xianchun" last="Tang">Xianchun Tang</name><affiliation wicri:level="2"><nlm:aff id="aff0020">Department of Cancer Immunology & AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cancer Immunology & AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Mollura, Daniel J" sort="Mollura, Daniel J" uniqKey="Mollura D" first="Daniel J." last="Mollura">Daniel J. Mollura</name><affiliation wicri:level="1"><nlm:aff id="aff0010">Center for Infectious Disease Imaging, National Institutes of Health Clinical Center, Bethesda MD 20892, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Infectious Disease Imaging, National Institutes of Health Clinical Center, Bethesda MD 20892</wicri:regionArea><wicri:noRegion>Bethesda MD 20892</wicri:noRegion></affiliation></author><author><name sortKey="Zeitlin, Larry" sort="Zeitlin, Larry" uniqKey="Zeitlin L" first="Larry" last="Zeitlin">Larry Zeitlin</name><affiliation wicri:level="1"><nlm:aff id="aff0025">Mapp Biopharmaceutical, Inc., San Diego CA 92121, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mapp Biopharmaceutical, Inc., San Diego CA 92121</wicri:regionArea><wicri:noRegion>San Diego CA 92121</wicri:noRegion></affiliation></author><author><name sortKey="Qin, Jing" sort="Qin, Jing" uniqKey="Qin J" first="Jing" last="Qin">Jing Qin</name><affiliation wicri:level="2"><nlm:aff id="aff0030">Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Huzella, Louis" sort="Huzella, Louis" uniqKey="Huzella L" first="Louis" last="Huzella">Louis Huzella</name><affiliation wicri:level="2"><nlm:aff id="aff0015">Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Bartos, Christopher J" sort="Bartos, Christopher J" uniqKey="Bartos C" first="Christopher J." last="Bartos">Christopher J. Bartos</name><affiliation wicri:level="2"><nlm:aff id="aff0015">Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Bohorova, Natasha" sort="Bohorova, Natasha" uniqKey="Bohorova N" first="Natasha" last="Bohorova">Natasha Bohorova</name><affiliation wicri:level="1"><nlm:aff id="aff0025">Mapp Biopharmaceutical, Inc., San Diego CA 92121, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mapp Biopharmaceutical, Inc., San Diego CA 92121</wicri:regionArea><wicri:noRegion>San Diego CA 92121</wicri:noRegion></affiliation></author><author><name sortKey="Bohorov, Ognian" sort="Bohorov, Ognian" uniqKey="Bohorov O" first="Ognian" last="Bohorov">Ognian Bohorov</name><affiliation wicri:level="1"><nlm:aff id="aff0025">Mapp Biopharmaceutical, Inc., San Diego CA 92121, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mapp Biopharmaceutical, Inc., San Diego CA 92121</wicri:regionArea><wicri:noRegion>San Diego CA 92121</wicri:noRegion></affiliation></author><author><name sortKey="Goodman, Charles" sort="Goodman, Charles" uniqKey="Goodman C" first="Charles" last="Goodman">Charles Goodman</name><affiliation wicri:level="1"><nlm:aff id="aff0025">Mapp Biopharmaceutical, Inc., San Diego CA 92121, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mapp Biopharmaceutical, Inc., San Diego CA 92121</wicri:regionArea><wicri:noRegion>San Diego CA 92121</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Do H" sort="Kim, Do H" uniqKey="Kim D" first="Do H." last="Kim">Do H. Kim</name><affiliation wicri:level="1"><nlm:aff id="aff0025">Mapp Biopharmaceutical, Inc., San Diego CA 92121, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mapp Biopharmaceutical, Inc., San Diego CA 92121</wicri:regionArea><wicri:noRegion>San Diego CA 92121</wicri:noRegion></affiliation></author><author><name sortKey="Paulty, Michael H" sort="Paulty, Michael H" uniqKey="Paulty M" first="Michael H." last="Paulty">Michael H. Paulty</name><affiliation wicri:level="1"><nlm:aff id="aff0025">Mapp Biopharmaceutical, Inc., San Diego CA 92121, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mapp Biopharmaceutical, Inc., San Diego CA 92121</wicri:regionArea><wicri:noRegion>San Diego CA 92121</wicri:noRegion></affiliation></author><author><name sortKey="Velasco, Jesus" sort="Velasco, Jesus" uniqKey="Velasco J" first="Jesus" last="Velasco">Jesus Velasco</name><affiliation wicri:level="1"><nlm:aff id="aff0025">Mapp Biopharmaceutical, Inc., San Diego CA 92121, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mapp Biopharmaceutical, Inc., San Diego CA 92121</wicri:regionArea><wicri:noRegion>San Diego CA 92121</wicri:noRegion></affiliation></author><author><name sortKey="Whaley, Kevin J" sort="Whaley, Kevin J" uniqKey="Whaley K" first="Kevin J." last="Whaley">Kevin J. Whaley</name><affiliation wicri:level="1"><nlm:aff id="aff0025">Mapp Biopharmaceutical, Inc., San Diego CA 92121, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mapp Biopharmaceutical, Inc., San Diego CA 92121</wicri:regionArea><wicri:noRegion>San Diego CA 92121</wicri:noRegion></affiliation></author><author><name sortKey="Johnson, Joshua C" sort="Johnson, Joshua C" uniqKey="Johnson J" first="Joshua C." last="Johnson">Joshua C. Johnson</name><affiliation wicri:level="2"><nlm:aff id="aff0015">Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Pettitt, James" sort="Pettitt, James" uniqKey="Pettitt J" first="James" last="Pettitt">James Pettitt</name><affiliation wicri:level="2"><nlm:aff id="aff0015">Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Ork, Britini L" sort="Ork, Britini L" uniqKey="Ork B" first="Britini L." last="Ork">Britini L. Ork</name><affiliation wicri:level="2"><nlm:aff id="aff0015">Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Solomon, Jeffrey" sort="Solomon, Jeffrey" uniqKey="Solomon J" first="Jeffrey" last="Solomon">Jeffrey Solomon</name><affiliation wicri:level="2"><nlm:aff id="aff0045">Clinical Research Directorate/Clinical Monitoring Research Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research,Frederick, MD 21702-USA.</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Clinical Research Directorate/Clinical Monitoring Research Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research,Frederick</wicri:cityArea></affiliation></author><author><name sortKey="Oberlander, Nicholas" sort="Oberlander, Nicholas" uniqKey="Oberlander N" first="Nicholas" last="Oberlander">Nicholas Oberlander</name><affiliation wicri:level="2"><nlm:aff id="aff0015">Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Zhu, Quan" sort="Zhu, Quan" uniqKey="Zhu Q" first="Quan" last="Zhu">Quan Zhu</name><affiliation wicri:level="2"><nlm:aff id="aff0020">Department of Cancer Immunology & AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cancer Immunology & AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Sun, Jiusong" sort="Sun, Jiusong" uniqKey="Sun J" first="Jiusong" last="Sun">Jiusong Sun</name><affiliation wicri:level="2"><nlm:aff id="aff0020">Department of Cancer Immunology & AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cancer Immunology & AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Holbrook, Michael R" sort="Holbrook, Michael R" uniqKey="Holbrook M" first="Michael R." last="Holbrook">Michael R. Holbrook</name><affiliation wicri:level="2"><nlm:aff id="aff0015">Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Olinger, Gene G" sort="Olinger, Gene G" uniqKey="Olinger G" first="Gene G." last="Olinger">Gene G. Olinger</name><affiliation wicri:level="2"><nlm:aff id="aff0015">Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Baric, Ralph S" sort="Baric, Ralph S" uniqKey="Baric R" first="Ralph S." last="Baric">Ralph S. Baric</name><affiliation wicri:level="4"><nlm:aff id="aff0035">Department of Microbiology and Immunology, Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599</wicri:regionArea><placeName><region type="state">Caroline du Nord</region><settlement type="city">Chapel Hill (Caroline du Nord)</settlement></placeName><orgName type="university">Université de Caroline du Nord à Chapel Hill</orgName></affiliation></author><author><name sortKey="Hensley, Lisa E" sort="Hensley, Lisa E" uniqKey="Hensley L" first="Lisa E." last="Hensley">Lisa E. Hensley</name><affiliation wicri:level="2"><nlm:aff id="aff0015">Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Jahrling, Peter B" sort="Jahrling, Peter B" uniqKey="Jahrling P" first="Peter B." last="Jahrling">Peter B. Jahrling</name><affiliation wicri:level="2"><nlm:aff id="aff0005">Emerging Viral Pathogens Section National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Emerging Viral Pathogens Section National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff0015">Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Marasco, Wayne A" sort="Marasco, Wayne A" uniqKey="Marasco W" first="Wayne A." last="Marasco">Wayne A. Marasco</name><affiliation wicri:level="2"><nlm:aff id="aff0020">Department of Cancer Immunology & AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cancer Immunology & AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author></analytic><series><title level="j">Virology</title><idno type="ISSN">0042-6822</idno><idno type="eISSN">1096-0341</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Monoclonal (administration & dosage)</term><term>Antibodies, Viral (administration & dosage)</term><term>Coronavirus Infections (drug therapy)</term><term>Coronavirus Infections (pathology)</term><term>Coronavirus Infections (virology)</term><term>Disease Models, Animal</term><term>Humans</term><term>Lung (pathology)</term><term>Lung (virology)</term><term>Macaca mulatta</term><term>Male</term><term>Middle East Respiratory Syndrome Coronavirus (physiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps antiviraux (administration et posologie)</term><term>Anticorps monoclonaux (administration et posologie)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie)</term><term>Humains</term><term>Infections à coronavirus (anatomopathologie)</term><term>Infections à coronavirus (traitement médicamenteux)</term><term>Infections à coronavirus (virologie)</term><term>Macaca mulatta</term><term>Modèles animaux de maladie humaine</term><term>Mâle</term><term>Poumon (anatomopathologie)</term><term>Poumon (virologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antibodies, Monoclonal</term><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Anticorps antiviraux</term><term>Anticorps monoclonaux</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Coronavirus Infections</term><term>Lung</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term><term>Lung</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Humans</term><term>Macaca mulatta</term><term>Male</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Macaca mulatta</term><term>Modèles animaux de maladie humaine</term><term>Mâle</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Middle East Respiratory Syndrome Coronavirus (MERS-CoV) was identified in 2012 as the causative agent of a severe, lethal respiratory disease occurring across several countries in the Middle East. To date there have been over 1600 laboratory confirmed cases of MERS-CoV in 26 countries with a case fatality rate of 36%. Given the endemic region, it is possible that MERS-CoV could spread during the annual Hajj pilgrimage, necessitating countermeasure development. In this report, we describe the clinical and radiographic changes of rhesus monkeys following infection with 5×10<sup>6</sup> PFU MERS-CoV Jordan-n3/2012. Two groups of NHPs were treated with either a human anti-MERS monoclonal antibody 3B11-N or E410-N, an anti-HIV antibody. MERS-CoV Jordan-n3/2012 infection resulted in quantifiable changes by computed tomography, but limited other clinical signs of disease. 3B11-N treated subjects developed significantly reduced lung pathology when compared to infected, untreated subjects, indicating that this antibody may be a suitable MERS-CoV treatment.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Adney, D R" uniqKey="Adney D">D.R. Adney</name></author><author><name sortKey="Van Doremalen, N" uniqKey="Van Doremalen N">N. van Doremalen</name></author><author><name sortKey="Brown, V R" uniqKey="Brown V">V.R. Brown</name></author><author><name sortKey="Bushmaker, T" uniqKey="Bushmaker T">T. Bushmaker</name></author><author><name sortKey="Scott, D" uniqKey="Scott D">D. Scott</name></author><author><name sortKey="De Wit, E" uniqKey="De Wit E">E. de Wit</name></author><author><name sortKey="Bowen, R A" uniqKey="Bowen R">R.A. 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Whaley</name><name sortKey="Zeitlin, Larry" sort="Zeitlin, Larry" uniqKey="Zeitlin L" first="Larry" last="Zeitlin">Larry Zeitlin</name><name sortKey="Zhu, Quan" sort="Zhu, Quan" uniqKey="Zhu Q" first="Quan" last="Zhu">Quan Zhu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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